Assessment of quality
The results of the quality assessment showed, the MINORS quality scores of 6 nonrandomized studies generated by MINORS ranged from 10 to 14. The item ‘Unbiased assessment of the study endpoint’ of all 6 single-arm studies were scored 0 because of the absence of description about blind evaluation of the endpoints (Table 2). The quality of two RCTs (Shitara 2020 and Peter 2017 ) was assessed by RoB2 and the two studies were rated as low risk (Figure 2). In brief, no study was excluded due to a high risk of bias.
Table 2. Quality assessment of included single-arm studies