Fig 2. CXCR1 and CXCR2 stimulate CDE-challenge induced Th2 gene expression and recruitment of GATA3 and Th2 cytokine expressing T-cells
(A ) Gata3 mRNA expressions in the BALF cells after CDE challenge in CDE-SCM and CDE-MCM mice at 28 h post-CDE challenge. (B-E ) at 28 h post-CDE challenge in CDE-MCM. (B )Gata3 mRNA expressions in BALF cells. (C ) Il4, Il5, Il13 , and Tgfb1 cells mRNA expressions in BALF cells at 28h after CDE challenge (D ) The lung mRNA expressions of Il4and Il13 at 28h post-CDE challenge. (E ) The number of IL4, IL5, IL13, and GATA3 expressing lung Th2-cells at 72h post-CDE challenge.
BALF; bronchoalveolar lavage fluid
CDE; cat dander extract
CDE-MCM; CDE-multiple challenge model
GATA3; GATA binding protein 3
Th2; T helper 2