FIGURE 1. The patient’s clinical features
A: Family pedigree. The black symbols represent patients withDICER1 syndrome. Our patient is represented by the red arrow.
PPB, pleuropulmonary blastoma; ERMS, embryonal rhabdomyosarcoma; MNG,
multinodular goiter. B–C: Pelvic magnetic resonance image of
the prostate tumor indicated by arrowheads. T1-weighted images with
gadolinium enhancement show a solid mass in the prostate gland that
constricts the urethra (B ) and a tumor at the trigone
protruding into the intraluminal space of the bladder (C ).D–E: Histology of the prostate tumor unveils two distinct
patterns: The first one is characterized by hypocellular proliferation
of polygonal cells with eccentric nuclei and eosinophilic cytoplasm with
an edematous stroma (D ), whereas the other exhibits a solid
proliferation of short spindle cells with nuclear enlargement and
hyperchromasia (E ). F –G : Histology of the
primary pleuropulmonary blastoma (F ) and the first relapse
(G ) similar to that of the prostate tumor.