Results:
Our study demonstrated a significant correlation between TB, and nodal involvement (P value=0.015), vascular invasion (P value=0.035), and mortality rate (P value=0.001), as well as a significant statistical correlation between high TB and extra-laryngeal extension (P value=0.006), clinical stage (P value=0.011), and mortality rate (P value=0.001). Moreover, small nest size was also associated with the clinical stage (P value=0.047), extra-laryngeal extension (P value=0.015), and mortality rate (P value=0.001). Based on our results, TB, CNS, and clinical stage are independent prognostic factors for mortality rate and are correlated with disease-free survival.