Variable Variable Single cell Small Intermediate Large P value
Age Age 58.8±8.4 60.21±6.7 60±7.56 87.27±8.2 0.515
Sex Male 37(94.9%) 43(91.5%) 24(100%) 14(77.8%) 0.066
Female 2(5.1%) 4(8.5%) 0 4(22.2%)
Tumor location Transglottic 31(79.5%) 36(76.6%) 15(62.5%) 14(77.8%) 0.465
Supraglottic 8(20.5%) 11(23.4%) 9(37.5%) 4(22.2%)
Histologic grade Well-differentiated 23(59%) 30(63.8%) 17(70.8%) 10(55.6%) 0.285
Moderately-differentiated 12(30.8%) 16(34%) 7(29.2%) 8(44.4%)
Poorly-differentiated 4(10.3%) 1(2.1%) 0 0
UICC/TNM stage II 2(5.1%) 9(19.1%) 4(16.7%) 6(33.3%) 0.047
III 5(12.8%) 12(25.5%) 7(29.2%) 4(22.2%)
IV 32(82.1%) 26(55.3%) 13(54.2%) 8(44.4%)
Nodal involvement Present 20(51.3%) 22(46.8%) 7(29.2%) 4(22.2%) 0.096
Absent 19(48.7%) 25(53.2%) 17(70.8%) 14(77.8%)
Extralaryngeal extension Present 31(79.5%) 23(48.9%) 13(54.2%) 8(44.4%) 0.015
Absent 8(20.5%) 24(51.1%) 11(45.8%) 10(55.6%)
Perineural invasion Present 13(33.3%) 14(29.8%) 4(16.7%) 4(22.2%) 0.640
Absent 26(66.7%) 33(70.2%) 20(83.3%) 14(77.8%)
Vascular invasion Present 8(20.5%) 11(23.4%) 2(8.3%) 1(5.6%) 0.203
Absent 31(79.5%) 36(76.6%) 22(91.7%) 17(94.4%)
Survival Disease-free patients 2(5.1%) 16(34%) 16(76.2%) 14(100%) 0.001
Recurrence and/or death 37(94.9%) 31(66%) 5(23.8%) 0