A study on the biological processes involved in YAP/TAZ and its role in
intestinal disease
Abstract
YAP/TAZ are two homologous transcriptional coactivators that promote
cell proliferation, stem cell maintenance, and tissue homeostasis.
Activated YAP/TAZ reflects the “social” behavior of cells, including
cell adhesion and mechanical signals that cells receive from tissue
structures and the surrounding extracellular matrix (ECM). Simultaneous
activation or overexpression of YAP/TAZ has been shown to lead to
cellular transformation and tumor development. Intestinal diseases are
mostly inflammatory and tumor-based, and YAP/TAZ plays an important role
in this process. However, many roles of the YAP/TAZ in the course of
intestinal disease are not clear. Therefore, this paper discusses the
YAP/TAZ-binding proteins, involved pathways, and related pathological
processes in the development of inflammatory bowel disease and
intestinal cancer disease.