Abstract Objectives; to evaluate the quality of life among patients with chronic rhino sinusitis and the risk of developing depression. Design; An observation cross section study. Setting; the quality of life was assessed using 2-item sinonasal outcome test (SNOT-22) while Patient Health Questionnaire-2 (PHQ-2) used for screen of depression and Stress was analyzed using the Kessler Psychological Distress Scale (10 items representing five psychological distress traits were assessed with a five-point scale) Participants; 1072 patients with chronic rhino sinusitis. Main outcome measures; Influence of Chronic Rhino sinusitis on Quality of Life and Risk of Depression and Lost Productivity. Results; the level of quality of life affection was moderate in 159 (24.77%) and severe in 483 (75.23%) of participants with CRS. The mean score of PHQ-2 for assessing the risk of major depression was 4.17 + 1.74 in participants with CRS. 135 (21.03%) were normal (not at risk of major depression) and 507 (78.97%) were at risk of major depression. According to the Kessler Psychological Distress Scale: 759 patients (70.8%) were positive with a mean total perceived stress score of 16.92 ± 7.34, whereas 313(29.2%) were negative with a mean total perceived stress score of 6.08 ± 2.7. The difference was statistically significant Conclusions; Patients with CRS are at risk of depression, poor quality of life and bad work performance. Despite the supportive treatment that used to provide to such patients, a clinical comprehensive approach should be considered to relief the impact on patients’ quality of life.