Dengue is a viral disease transmitted by mosquitoes that in recent years has spread rapidly across all continents. The dengue virus is transmitted by female mosquitoes, mainly of the Aedes aegypti species and, to a lesser extent, of the Aedes albopictus species. There are four distinct but closely related serotypes of the virus that causes dengue (DENV-1, DENV-2, DENV-3 and DENV-4). The present study evaluated and reviewd the temporal spreading and molecular evolution of dengue virus serotypes worldwide. A total of 1,581 dengue virus whole-genome sequences (WGSs) with available information from the country and sampling date (Jan/1944 – Jul/2022), were obtained. Bayesian coalescent analyses with dengue virus WGS were performed to study viral phylodynamic and phylogeography. The time of the Most Recent Common Ancestor (tMRCA) and 95% highest posterior density (HPD 95%) were estimated for each serotype. Bayes factor (BF) was determined to infer phylogeographic data. The results demonstrated that the tMRCA of DENV-1 was 1884-11-15 (HPD95%: 1882-01-28; 1890-08-27) in Southeast Asia, DENV-2 was 1723-01-29 (HPD95%: 1714-05-22; 1728-10-09) in Europe, DENV-3 was 1921-04-12 (HPD95%: 1918-05-25; 1924-03-13) in Southeast Asia, and DENV-4 was 1876-03-28 (HPD95%: 1865-08-02; 1899-08-27) in Southeast Asia. The molecular origin of the dengue virus was in Spain in 1682 (BF=38), later it was disseminated in Asia (Indonesia; BF=15) and Oceania (Papua New Guinea, BF=13) in 1847. After this period, the virus presented dissemination in Asia (Malaysia, BF=13; India, BF=28; and China BF=30) and in North America (USA; BF=35) in 1890. In South America, it was first disseminated to Ecuador in 1897 (BF=15) and then to Brazil in 1910 (BF=38). During this same period there were disseminations to countries such as Puerto Rico (BF=18) and to the African continent (Senegal; BF=14). After this period, the virus was widely disseminated, especially in the American and Asian continents. The dengue disease has had a significant impact on global health worldwide and the present study provides an overview of the molecular evolution of dengue virus serotypes (from 1944 to 2022).