Introduction & Objective: Recently, the utilization of herbals for the biosynthesis of nanoparticles has been noticed in their properties such as environmental compatibility, simplicity, and economics. Numerous medicinal plants possess the ability to synthesize nanoparticles that have applications in medicine, biosciences, and the pharmaceutical industry. The primary objective of this research is to propose an environmentally friendly approach for synthesizing silver nanoparticles (AgNPs) for use in drug delivery, medicine, industry. Methods: First, the polygonum aviculare L. extract was prepared by maceration and synthesized by 2 mM AgNO 3 solution using the green method. After changing the color of the extract, confirmation of the formation of nanoparticles by UV-Vis spectroscopy, and Morphological investigation by TEM, FE-SEM, XRD and FT-IR to examine functional groups in nanoparticles and investigation of antioxidant and antibacterial activities of nanoparticles by DPPH assay and Disk Diffusion method. Results: The emergence of an absorption peak between the wavelengths of 400-450 nm on the UV-Vis spectrophotometer indicates the synthesis of silver nanoparticles. The shape of spherical and rod particles, their average size is about 25-70 nm. The free radical scavenging activity was calculated as IC 50 = 15.63 mg/L. The synthesized silver nanoparticles had significant antimicrobial activity. Conclusion: polygonum aviculare L. extract can reduce Ag + ions to silver nanoparticles. In addition, synthesized silver nanoparticles have good antioxidant and antimicrobial properties.