INTRODUCTIONMultiple Endocrine Neoplasia (MEN) 2A is an autosomal dominant syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma (PCC) and parathyroid tumors.[1-4] Caused by germ-line mutation in the RET proto-oncogene located on chromosome 10, MEN-2A is a subtype of the MEN-2 syndrome and is the more commonly encountered clinical variant (accounting for 75% cases) as opposed to MEN-2B.[5,6] Almost 90% afflicted individuals manifest with MTC while PCC and parathyroid tumors are noted in upto 40-50% and 20-30% cases respectively. As the disease may present with polyglandular involvement, screening of other endocrine organs is imperative once any single organ involvement is detected. Current literature on diagnosis and management of MEN-2A syndrome in pregnancy is scant and largely comprises case series or case reports. Most patients were incidentally detected to have hypertension during routine antenatal screening and found to have an underlying pheochromocytoma. The limitations imposed by pregnancy both in terms of restricted imaging options due to radiation exposure to the fetus and restricted period of surgical intervention in the second trimester makes the management of this situation challenging in most cases. We share our experience of a young woman with MEN 2A syndrome who became pregnant immediately post adrenalectomy for pheochromocytoma and had to undergo surgery for medullary thyroid carcinoma in second trimester during a nationwide lockdown due to the ongoing COVID pandemic. The case highlights the various challenges we faced in patient management, surgical intervention, post-operative care and follow up amidst travel restrictions during the lockdown along with how these challenges were overcome through multidisciplinary teamwork, teleconsultation services and shared decision making with the patient which led us to a successful outcome in a difficult clinical scenario, in such challenging times.